peritonitis - secundair (perforatie)
Advices
Priority | Medication | Remarks |
---|---|---|
Priority: 1st choice |
Medication: cefuroxim iv 1500mg 3dd 5 to 14 days +
metronidazol iv 500mg 3dd 5 to 14 days +
gentamicine iv 5mg/kg 1dd maximum 3 days |
Remarks:
Tenminste een eenmalige gift gentamicine tenzij pre-existente eGFR <30 ml/min Zie opmerking mbt doseren gentamicine Metronidazol kan ook per os in dezelfde dosering |
Priority: 1st choice alternative |
Medication: ceftriaxon iv 2000mg 1dd 5 to 14 days +
metronidazol iv 500mg 3dd 5 to 14 days |
Remarks:
Bij contra-indicatie voor gentamicine (pre-existente eGFR <30 ml/min) Metronidazol kan ook per os in dezelfde dosering |
Priority | Medication | Remarks |
---|---|---|
Priority: 1st choice |
Medication: piperacilline/tazobactam iv 4000/500mg 4dd 5 to 14 days |
Remarks:
Bij perforatie hoge tractus digestivus overweeg bijstarten caspofungin iv < 80 kg, 70 mg oplaad, nadien 1 dd 50 mg; >80 kg 1 dd 70 mg, in afwachting van kweekuitslagen |
Priority | Medication | Remarks |
---|---|---|
Priority: 1st choice |
Medication: meropenem iv 1g 3dd |
Priority | Medication | Remarks |
---|---|---|
Priority: 1st choice |
Medication: piperacilline/tazobactam iv 4000/500mg 4dd |
Remarks:
Bij bewezen gevoeligheid voor piperacilline/tazobactam |
Sources
-
Pubmed.gov publication # 25992746
Trial of short-course antimicrobial therapy for intraabdominal infection. Sawyer RG, Claridge JA, Nathens AB, et al. N Engl J Med. 2015 May 21;372(21):1996-2005.
Antimicrobial resources
The following antimicrobial agents have been used in these recommendations:
External antimicrobial resources
Menu position
Metadata
Swab vid: G-217796.24
Updated: 03/01/2024 - 16:00
Status: Published
General comments
Gentamicine
Continu doseren:
Iv orale switch
Behandelduur
*AmpC-producerende bacteriën
Algemeen